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The Relationship Between Lower Vitamin D Levels and Hearing Loss in Older Adults

Article information

J Audiol Otol. 2024;28(4):252-259
Publication date (electronic) : 2024 July 9
doi : https://doi.org/10.7874/jao.2023.00458
1Department of Otorhinolaryngology-Head and Neck Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
2University of Ulsan College of Medicine, Seoul, Korea
Address for correspondence Jong Woo Chung, MD, PhD Department of Otorhinolaryngology-Head and Neck Surgery, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Korea Tel +82-2-3010-3718 Fax +82-2-489-2773 E-mail jwchung@amc.seoul.kr
*These authors contributed equally to this work.
†Current affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Soonchunhyang University College of Medicine, Seoul, Korea
Received 2023 September 16; Revised 2023 December 15; Accepted 2023 December 27.

Abstract

Background and Objectives

Age-related hearing loss (ARHL) is a sensorineural disease that is associated with a number of factors. In addition to age, sex, environment, lifestyle, and comorbidities are all known to be related to ARHL as well. The prevalence of ARHL can be reduced by controlling the adjustable factors that cause it. Vitamin D levels are strongly related to calcium metabolism, which can affect ARHL. This study aimed to investigate the association between vitamin D and ARHL.

Subjects and Methods

A total of 1,104 subjects aged >65 years were enrolled from the fifth Korean National Health and Nutrition Examination Survey, which was conducted from 2010-2012. Every participant received both an audiological assessment and a nutritional survey. The association between ARHL and serum vitamin D concentration was analyzed using logistic regression analyses with complex sampling adjusted for confounding factors such as alcohol consumption, smoking status, mobility, and bone mineral density.

Results

Our multivariable analysis revealed that males in the group with lower serum levels of vitamin D (< 20 ng/mL) had a higher prevalence of ARHL (odds ratio, 1.638, 95% confidence interval, 1.058-2.538, p=0.027).

Conclusions

This finding suggests that lower serum levels of vitamin D are associated with ARHL in the older male population.

Introduction

Age-related hearing loss (ARHL) is gradual, bilateral, and symmetrical sensorineural hearing impairment, which occurs when there is deterioration in the cochlea and related inner ear structures [1]. ARHL interrupts understanding and perception of speech, causing more serious problems such as depression and social isolation. Ultimately, ARHL affects physical, cognitive, and emotional function and leads to a decline in the patient’s quality of life [2].

According to the recent large scaled study, 1 of 5 people are experiencing a large burden of hearing loss in the United States [3]. Aging population will be more affected by this condition in the future [3].

ARHL is an irreversible disease; therefore, identifying potential factors that may lower the risk of ARHL and making necessary adjustments to prevent its onset is of utmost importance. A variety of factors related to ARHL have been reported, such as aging, noisy environment, systemic disorder, and nutritional factor [2,4-6]. Among these factors, the nutritional aspect is easy to modulate for elderly people [7]. Emerging studies have emphasized the use of nutrient supplementation, such as vitamin A and B supplementation, for the purpose of preventing hearing loss [5].

Recently, several studies have revealed that the calcium metabolism has relationship with ARHL [8-13]. Osteoporosis is a systemic disorder caused by the imbalance between bone formation and resorption [11]. Osteoporosis is marked by reduced bone mineral density (BMD) and increased vulnerability of bones, primarily impacting the proximal femur and spine [11]. Osteoporosis also affects the bony structures of ear and otic capsule [8]. When those components have microfractures due to osteoporosis, hearing loss occurs [13]. Thus, modifying BMD can prevent ARHL [9]. Furthermore, a study reported that calcium regulates the force sensitivity of the hair cell transduction channel and amplifies sound stimuli [12].

Vitamin D plays an important role in correcting abnormal calcium metabolism [14]. Vitamin D facilitates absorption of calcium and phosphorus in the intestines [15]. The transcellular pathway is an active process to transport calcium that is highly regulated by vitamin D [14]. An adequate serum vitamin D level activates calcium transport, which prevents osteoporosis and maintains calcium homeostasis [4,12]. The relationship between calcium metabolism and ARHL has already been shown in many studies, but there are not many additional studies on the relationship between vitamin D and ARHL. In this study, we aimed to determine the potential impact of vitamin D status on ARHL using data from the fifth Korean National Health and Nutrition Examination Survey (KNHANES).

Subjects and Methods

Study participants

The KNHANES, a nationwide epidemiological study is conducted by the Korean Centers for Disease Control and Prevention under the Ministry of Health and Welfare, with annual Institutional Review Board (IRB) approval. Individuals are chosen randomly from districts within cities and provinces in South Korea among the chosen individuals, 80.8% of participants were involved in the fifth KNHANES from 2010 to 2012. There was a total of 25,534 participants, and the study included 10,152 participants aged over 50 years. Through the questionnaire, subjects with a history of head and neck cancer, chemotherapy, radiation therapy and workers in noisy environments were excluded. Among the 10,152 participants, 2,730 participants were excluded because either they did not have hearing test data or the difference in the dB level on a hearing test between each ear was greater than 15 dB. Then, 4,656 participants without serum vitamin D levels or BMD data were excluded from the analysis. Of the 2,766 participants, we planned to analyze the relationship between serum vitamin D and ARHL, we focused 1,104 participants who were older than 65 years old.

Otologic examination and audiologic evaluation

During the fifth KNHANES survey, otologic examinations were conducted by otolaryngology doctors by using a 4 mm, 0º endoscope (Xion GmbH, Berlin, Germany) to assess any anomalies associated with the eardrum or middle ear, such as retraction, otitis media with effusion, and cholesteatoma. Audiologic evaluation was conducted at 0.5, 1, 2, 3, 4, and 6 kHz in a soundproof booth. All participants underwent an otolaryngologic exam, and only those with normal tympanic membranes were included. ARHL was defined when the air conduction thresholds exceed an average of 25 dBs on pure tone audiometry at 0.5, 1, 2, and 4 kHz on both side of ears.

Definition of serum vitamin D deficiency

According to the Institute of Medicine, almost every individual has a serum vitamin D level of at least 20 ng/mL, which means that this level can be used as the definition of an adequate vitamin D status [16]. The clinical guideline defines vitamin D deficiency as having a level less than 20 ng/mL [17]. In a previous study analyzing the relationship between vitamin D and ARHL based on National Health and Nutrition Examination Survey (NHANES) data, the same cut-off was applied to vitamin D levels [4]. Based on these references, we also defined serum vitamin levels below 20 ng/mL as vitamin D deficiency in our study.

Quality of life assessment

The Euro Quality of Life-5 Dimension (EQ-5D) questionnaire is a commonly employed tool in Europe that can be used to assess generic quality of life and has been employed to investigate health-related quality of life (HRQoL) [18]. Each part of the EQ-5D (mobility, self-care, usual activities, pain/discomfort, and anxiety/depression) is measured with one question, and there are three possible answers (1=no problem, 2=moderate problem, 3=severe problem) [18]. The detailed descriptions of each response in the mobility section are as follows: “I have no problems walking about,” “I have some problems walking about,” and “I am confined to bed.” This questionnaire has been also used to investigate HRQoL in Korea and is measured by the KNHANES [19]. It was noted that elderly Koreans with vitamin D deficiency were more prone to experiencing difficulties in terms of mobility, self-care, and their usual daily activities [19]. In this study, we used self-reported answers, specifically in dimension of “mobility,” which was considered to have close association with vitamin D status and bone health, to evaluate relationship with ARHL.

BMD evaluation

The BMD of the total proximal femur, femoral neck, and lumbar spine was calculated by using dual-energy X-ray absorptiometry [20]. According to the World Health Organization, osteoporosis is diagnosed by T-score thresholds. A T score ≥-1.0 is considered normal. Osteopenia is defined when a T score falls within the range of -2.5 and -1.0. A T score below -2.5 is considered osteoporosis [21].

Statistical analysis

Univariate analyses were conducted to assess the association between serum vitamin D levels and hearing impairment, while multivariable logistic regression analyses were employed to investigate this association in a more comprehensive manner. Statistical methods were applied to account for the complex sampling design and the utilization of sampling weights from the fifth KNHANES. For categorical variables, data are displayed as the number of cases with a weighted percentage. The analyses were controlled for the subsequent potential confounding factors: age, sex, EQ-5D, smoking status, alcohol consumption, osteoporosis, and diabetes mellitus. Additionally, we performed a sex-stratified analysis for controlling significant confounding factor. The results of the logistic regression analyses are expressed as odds ratios (ORs) with 95% confidence intervals. A p value <0.05 was considered statistically significant. All statistical analyses were performed by SAS 9.4 (SAS Institute Inc, Cary, NC, USA).

Ethics statement

The study protocol for the analysis of the data was approved by the IRB of Asan Medical Center (2020-1753).

Results

The baseline characteristics of study participants are shown in Table 1. The occurrence of ARHL was 58.97% (n=651) in the age group older than 65 years. ARHL occurred in 64.38% (n=329) of men and 54.30% (n=322) of women. When comparing the “mobility” of EQ-5D, subjects with ARHL had lower HRQoL than those without ARHL. Furthermore, those with ARHL were not likely to drink but were more likely to smoke than those without ARHL. In the ARHL group, ex-smokers accounted for 31.18% and current smokers 15.89%, whereas in the normal hearing group, the proportions were lower at 27.69% and 10.81%, respectively, showed lower proportions.

Baseline characteristics of the study participants

Table 2 shows an evaluation of factors associated with ARHL. In the univariate analysis, “moderate problems” in mobility according to the EQ-5D (p=0.003) showed an increased risk of ARHL. In addition, female sex (p=0.007) and “no problem” in mobility according to EQ-5D (p=0.009) were associated with a lower risk of ARHL on univariate analysis. In the multivariable analysis adjusted for age, sex, alcohol consumption, smoking status, diabetes, EQ-5D, BMD, and serum vitamin D level, “moderate problems” in mobility (EQ-5D) (p=0.005) and osteoporosis (p=0.015) were associated with a high risk of ARHL. Female subjects (p<0.001) and participants with “no problem” in mobility (EQ-5D) (p=0.019) showed a lower risk for ARHL on multivariable analysis.

ORs of factors associated with ARHL

As shown in Table 3, we studied whether men and women with low serum vitamin D levels differentially developed ARHL. In the univariate analysis, men with a “moderate problem” in mobility (EQ-5D) (p=0.001), osteopenia (p=0.033), and a low serum vitamin D level (p=0.045) had a higher risk of ARHL. Women showed a higher risk of ARHL when they had factors such as “moderate” problems in mobility (EQ-5D) (p=0.020) and osteoporosis (p=0.021). In the multivariable analysis, a low serum vitamin D level (p=0.027) and “moderate” problems in mobility (EQ-5D) (p=0.007) were significantly associated with a higher risk of ARHL in men; however, this finding was not significant in women. Additionally, we conducted propensity score matching analysis to adjust the age factor in each sex group (Table 4).

ORs of factors associated with ARHL in men and women

Odds ratios of vitamin D level (<20 vs. ≥20 ng/mL) associated with ARHL in men and women after matching age

Before conducting matching, each group was divided into two subgroups based on vitamin D levels (<20 vs. ≥20 ng/mL). The mean age was about 71 years for all groups. After age matching, in the adjusted model of men and women, the ORs were 1.560 (p=0.082) and 1.081 (p=0.715), respectively.

Discussion

In this cross-sectional study, the relationship between serum vitamin D level and ARHL was investigated among the elderly. A low serum vitamin D level, defined as total vitamin D level <20 ng/mL, was associated with ARHL in elderly men who were the participants in the KNHANES. There was significant relationship even when other confounding variates were adjusted for. This finding is in accordance with that of previous studies that investigated the association between vitamin D, calcium, BMD, and hearing loss [4,22].

According to a recent cross-sectional study based on the same raw data, analyzing the association between age and hearing of Korean, it has been reported that there is a significant decrease in the threshold of high-frequency hearing with advancing age [23]. This decrease is particularly pronounced in patients aged 65 and above, showing a marked increase. In another prior study using KNHANES data, they considered patients aged 65 and above with bilateral hearing loss, referred to as ARHL [5]. As our study includes participants with a hearing difference of 15 dB or less between both ears, normal otoscopic findings, and excludes individuals with head and neck cancer, those undergoing cancer treatment, radiation exposure, and those working in noisy environments, although it was challenging to definitively discern sensorineural hearing loss through thorough bone conduction test results, we concluded that it would be appropriate to describe the participants as having ARHL.

In recent studies conducted in the United States, using data from NHANES, there have been reports indicating an association between vitamin D deficiency and hearing loss in the elderly population [4,24]. Our research findings, consistent with those results, elucidated the association between the risk of ARHL and low level of vitamin D among elderly Korean men. This study showed that men with an inadequate vitamin D status have an approximately 58% higher risk than men with an adequate vitamin D status. Even when adjusting for confounders, an insufficient vitamin D level in elderly men was associated with an approximately 64% higher risk than men with a sufficient serum vitamin D level.

The strength of this study is in the inclusion of a large number of individuals with adjustments for age, sex, systemic disease, and other confounding factors that are previously known as possible risk factors for ARHL. Furthermore, using audiometry data for elderly participants in the KNHANES is also a strength because self-reported hearing loss is not accurate enough [25]. In Table 4, to minimize the influence of age factors on the analysis results, additional propensity score matching analysis was conducted. While the statistical significance of our results diminished due to the reduction in sample size resulting from the procedure of comparing subjects with identical age profiles, our adjusted model for males did reveal a marginally significant association, demonstrating a consistent directional and magnitude trend in the ORs (1.560, p=0.082). Prior to matching, there was no significant difference in the age distribution according to the level of vitamin D (Table 4). Because we adjusted for this in our multivariable analysis, we believe it is appropriate to focus on these results as the primary outcome.

Osteoporosis and low calcium status have been known to cause hearing loss in the elderly in some clinical studies [1,8-10,13]. Nutritional factors have been shown to be a cause of osteoporosis [14,26]. Vitamin D deficiency can interrupt calcium intake in the intestines, which can affect the balance between bone resorption and bone formation [11,14,20]. Systemic osteoporosis affects the middle ear bone and otic capsule which, as a result, impairs hearing function [9,13,27,28]. There was a suggestion that interactions between transforming growth factor β and vitamin D play a role in regulating osteoblasts, which could affect the mechanical characteristics of the cochlear bone and lead to sensorineural hearing loss [29,30]. Therefore, the potential mechanism by which vitamin D deficiency causes ARHL could have been related to bone metabolism.

Several research findings indicate that vitamin D could have an impact on hearing loss, specifically in the inner ears connected to the cochlea or the auditory nerve [24,31]. Mice lacking vitamin D receptors exhibit degenerative characteristics in the spiral ganglia and hair cells of the cochlea, leading to the development of gradual hearing impairment [32]. The proposed mechanisms center around vitamin D receptors in the auditory system, influencing calcium homeostasis in inner ear bones responsible for sound transduction, as well as affecting inner ear fluids, and hair cells [33].

Furthermore, changes in calcium homeostasis could be due to another mechanism [12,34]. Calcium entry through transduction channels leads to a fast negative movement in the mechanosensitive stereocilia of hair cells, which can amplify the signal in the cochlea [12]. In addition, calcium imbalances could accelerate oxygen-free radicals in hair cells and eventually lead to ARHL [34]. In summary, vitamin D deficiency may either have a direct impact on auditory function within the auditory organs or potentially lead to hearing loss through the dysregulation of calcium or bone metabolism.

In the results of this study, it was revealed that there was a correlation between ARHL and low vitamin D levels only in elderly men. According to a previous study, hearing loss appears to be more common in women in relation to metabolic syndrome [35]. In another study, there has been a reported significant association in women between hearing thresholds and visceral adipose tissue [36]. Considering factors such as sex-specific hormones and endocrine system that may influence auditory function, it is thought that further research taking into account these various factors is necessary.

As a cross-sectional epidemiological study, this study could not define causality between ARHL and vitamin D status. A number of KNHANES participants for whom vitamin D or BMD data were not available could not be enrolled in this analysis. Furthermore, variables, such as history of chronic kidney disease and head trauma that can affect ARHL and vitamin D status were not evaluated. The serum calcium, phosphorus, and parathyroid hormone level, which may potentially impact vitamin D levels, were not obtainable from the KNHANES data. As such, we acknowledge these as constraints to our research. Further studies with an adequate sample size that address possible confounding factors are needed.

In conclusion, this study shows epidemiological information that a low vitamin D level is associated with a risk of ARHL among men aged over 65 years. Men who are vitamin D deficient should be considered a risk group for ARHL compared with men with an adequate vitamin D status. Therefore, maintaining sufficient supplies of vitamin D in the elderly will help reduce the incidence of ARHL.

Notes

Conflicts of Interest

The authors have no financial conflicts of interest.

Author Contributions

Conceptualization: Jong Woo Chung. Data curation: Yun Ji Lee, Jun Ho Jung. Formal analysis: Jun Ho Jung. Investigation: Jun Ho Jung. Methodology: Jong Woo Chung. Project administration: Jong Woo Chung. Resources: Jong Woo Chung. Supervision: Jong Woo Chung. Validation: Yun Ji Lee. Visualization: Yun Ji Lee. Writing—original draft: Yun Ji Lee, Jun Ho Jung. Writing—review & editing: Yun Ji Lee. Approval of final manuscript: all authors.

Funding Statement

None

Acknowledgements

The authors wish to pay special thanks to Ye-Jee Kim and Min-Ju Kim in the Department of Clinical Epidemiology and Biostatistics, Asan Medical Center, University of Ulsan College of Medicine for contributing to the statistical analysis and to the Wordvice for English editing.

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Article information Continued

Table 1.

Baseline characteristics of the study participants

Characteristics ARHL
No (n=453)
Yes (n=651)
N Weighted N Weighted % N Weighted N Weighted %
Sex
 Male 182 436,916 37.80 329 810,801 47.65
 Female 271 718,821 62.20 322 890,927 52.35
Alcohol consumption
 None 209 545,136 47.17 302 803,350 47.85
 <1 (per month) 77 196,658 17.02 91 254,684 15.17
 1-4 (per month) 72 166,887 14.44 114 294,372 17.53
 2-3 (per week) 48 109,412 9.47 64 150,434 8.96
 ≥4 (per week) 47 137,645 11.91 70 176,206 10.49
Smoking
 Never 272 710,743 61.50 333 891,433 52.93
 Former 131 320,044 27.69 208 525,055 31.18
 Current 50 124,950 10.81 103 267,627 15.89
Diabetes
 No 362 919,336 79.55 525 1,398,612 82.19
 Yes 91 236,401 20.45 126 303,116 17.81
Hypertension
 No 221 554,180 47.95 313 806,411 47.39
 Yes 232 601,557 52.05 338 895,318 52.61
Mobility (EQ-5D)*
 No problem 308 745,789 64.57 364 901,099 53.45
 Moderate problem 138 392,038 33.94 268 748,619 44.40
 Severe problem 6 17,155 1.49 13 36,221 2.15
Serum vitamin D level (ng/mL)
 <20 265 650,764 56.31 398 1,041,338 61.19
 ≥20 188 504,973 43.69 253 660,391 38.81
BMD
 Normal 92 231,240 20.01 114 275,918 16.21
 Osteopenia 211 541,045 46.81 298 731,737 43.00
 Osteoporosis 150 383,452 33.18 239 694,073 40.79
*

Numbers are less than group total because of missing data.

ARHL, age-related hearing loss; EQ-5D, Euro Quality of Life-5 Dimension; BMD, bone mineral density

Table 2.

ORs of factors associated with ARHL

Factor Univariate analysis
Multivariable analysis
OR (95% CI) p OR (95% CI) p
Age 1.141 (1.098-1.186) <0.001*** 1.133 (1.090-1.177) <0.001***
Sex
 Male Reference Reference
 Female 0.668 (0.499-0.893) 0.007** 0.303 (0.177-0.521) <0.001***
Alcohol
 None Reference Reference
 <1 (per month) 0.879 (0.588-1.312) 0.526 0.984 (0.615-1.575) 0.946
 1-4 (per month) 1.197 (0.782-1.833) 0.407 1.286 (0.817-2.024) 0.276
 2-3 (per week) 0.933 (0.544-1.600) 0.800 0.745 (0.407-1.363) 0.338
 ≥4 (per week) 0.869 (0.552-1.366) 0.541 0.684 (0.399-1.173) 0.167
Diabetes
 No Reference Reference
 Yes 0.843 (0.584-1.217) 0.361 0.800 (0.540-1.186) 0.265
Mobility (EQ-5D) 0.009** 0.019**
 No problem Reference Reference
 Moderate problem 1.580 (1.172-2.132) 0.003** 1.596 (1.150-2.216) 0.005**
 Severe problem 1.747 (0.710-4.299) 0.223 1.578 (0.696-3.581) 0.274
Serum vitamin D level (ng/mL)
 ≥20 Reference Reference
 <20 1.224 (0.913-1.649) 0.176 1.300 (0.957-1.766) 0.092
BMD 0.115 0.051
 Normal Reference Reference
 Osteopenia 1.133 (0.779-1.649) 0.511 1.326 (0.899-1.956) 0.155
 Osteoporosis 1.517 (0.978-2.352) 0.063 1.888 (1.132-3.148) 0.015*
*

p<0.05;

**

p<0.01;

***

p<0.001.

OR, odds ratio; ARHL, age-related hearing loss; CI, confidence interval; EQ-5D, Euro Quality of Life-5 Dimension; BMD, bone mineral density

Table 3.

ORs of factors associated with ARHL in men and women

Factor Men
Women
Univariate analysis
Multivariable analysis
Univariate analysis
Multivariable analysis
OR (95% CI) p OR (95% CI) p OR (95% CI) p OR (95% CI) p
Age 1.112 (1.052–1.176) <0.001*** 1.108 (1.049–1.172) <0.001*** 1.168 (1.114–1.225) <0.001*** 1.155 (1.098–1.214) <0.001***
Alcohol
 None 1 1 1 1
 <1 (per month) 1.018 (0.479–2.164) 0.963 0.866 (0.380–1.974) 0.731 0.798 (0.494–1.289) 0.355 0.992 (0.560–1.757) 0.977
 1-4 (per month) 0.910 (0.486–1.704) 0.767 1.108 (0.562–2.184) 0.767 1.097 (0.693–2.028) 0.768 1.393 (0.729–2.663) 0.315
 2-3 (per week) 0.613 (0.324–1.159) 0.132 0.634 (0.323–1.247) 0.186 0.869 (0.271–2.790) 0.813 0.959 (0.317–2.903) 0.941
 ≥4 (per week) 0.565 (0.294–1.087) 0.087 0.663 (0.343–1.281) 0.220 0.743 (0.229–2.413) 0.620 0.523 (0.147–1.866) 0.317
Diabetes
 No 1 1 1 1
 Yes 0.963 (0.557–1.665) 0.891 0.715 (0.397–1.288) 0.263 0.822 (0.505–1.340) 0.431 0.823 (0.495–1.366) 0.449
Mobility (EQ-5D)
 No problem 1 1 1 1
 Moderate problem 2.615 (1.455–4.698) 0.001** 2.488 (1.283–4.825) 0.007** 1.574 (1.073–2.308) 0.020* 1.264 (0.821–1.945) 0.285
 Severe problem NE NE 1.579 (0.500–4.991) 0.435 0.925 (0.338–2.530) 0.879
Serum vitamin D level (ng/mL)
 ≥20 1 1 1 1
 <20 1.576 (1.010–2.461) 0.045* 1.638 (1.058–2.538) 0.027* 1.123 (0.711–1.773) 0.618 1.053 (0.651–1.704) 0.832
BMD
 Normal 1 1 1 1
 Osteopenia 1.620 (1.041–2.519) 0.033* 1.523 (0.956–2.425) 0.076 1.429 (0.579–3.527) 0.438 1.029 (0.413–2.561) 0.951
 Osteoporosis 2.063 (0.952–4.470) 0.066 1.336 (0.591–3.021) 0.485 2.772 (1.166–6.590) 0.021* 1.641 (0.689–3.908) 0.262
*

p<0.05;

**

p<0.01;

***

p<0.001.

OR, odds ratio; ARHL, age-related hearing loss; CI, confidence interval; EQ-5D, Euro Quality of Life-5 Dimension; BMD, bone mineral density

Table 4.

Odds ratios of vitamin D level (<20 vs. ≥20 ng/mL) associated with ARHL in men and women after matching age

Before matching
After age matching
Men
Women
Men
Women
<20 (n=273) ≥20 (n=238) <20 (n=390) ≥20 (n=203) <20 (n=226) ≥20 (n=226) <20 (n=200) ≥20 (n=200)
Mean age (95% CI) 70.95 (70.38-71.51) 71.44 (70.81-72.07) 71.74 (71.14-72.34) 71.45 (70.70-72.19) 71.11 (70.56-71.66) 71.11 (70.56-71.66) 71.01 (70.42-71.59) 71.01 (70.42-71.59)
OR (95% CI) p OR (95% CI) p OR (95% CI) p OR (95% CI) p
Crude 1.576 (1.010-2.461) 0.045 1.123 (0.711-1.773) 0.618 1.375 (0.915-2.066) 0.125 1.020 (0.693-1.500) 0.922
Adjusted 1.638 (1.058-2.538) 0.027 1.053 (0.651-1.704) 0.832 1.560 (0.946-2.574) 0.082 1.081 (0.711-1.644) 0.715

OR, odds ratio; ARHL, age-related hearing loss; CI, confidence interval