Korean J Audiol Search


J Audiol Otol > Epub ahead of print
DOI: https://doi.org/10.7874/jao.2018.00311    [Epub ahead of print] Published online March 13, 2019.
Effects of Dexmedetomidine Infusion During Sevoflurane Anesthesia on Otoacoustic Emissions
Mehmet İlhan Şahin1, Alperen Vural1, Aynur Akın2, İbrahim Ketenci1, Yaşar Ünlü1
1Department of Otolaryngology, Erciyes University Faculty of Medicine, Kayseri, Turkey
2Department of Anesthesia, Erciyes University Faculty of Medicine, Kayseri, Turkey
Correspondence  Mehmet İlhan Şahin ,Tel: +90 352 207 6666 (ext 21457), Fax: +90 352 207 6600, Email: misahin@erciyes.edu.tr
Submitted: August 13, 2018  Accepted after revision: October 28, 2018
Background and Objectives
Knowing the ototoxic potential of the agents used in medical treatments is important for the protection of hearing. Although we have knowledge regarding some effects of dexmedetomidine, which is an anesthetic-sparing drug, its influence over the hearing system has never been studied and is obscure yet. The aim of this study is to determine the effects of intravenous dexmedetomidine application during sevoflurane anesthesia on otoacoustic emissions (OAEs).
Subjects and Methods
This prospective randomized study was performed on 60 patients (34 male, 26 female, mean age: 30.6±9.2 years) who were scheduled for an elective surgery under general anesthesia and the patients were enrolled and randomly divided into 2 groups. They received dexmedetomidine (Group D) or Saline (Group S) infusion during a standardized Sevoflurane anesthesia. Transient and distortion product OAEs were measured preoperatively and postoperatively (24th hour). OAE results were compared within and between groups.
In group D postoperative OAEs were lower than preoperative OAEs and postoperative levels of group S, especially at low frequencies (p<0.05).
Dexmedetomidine infusion affects the micromechanical function of cochlea especially in the low-frequency region. Dexmedetomidine should be carefully used during general anesthesia to avoid its probable harmful effects on cochlear micromechanics.
Keywords: Dexmedetomidine · Adrenergic alpha-2 receptor agonists · Otoacoustic emissions · Sevoflurane · Inhalational anesthetics


Browse all articles >


Browse all articles >

Editorial Office
Department of Otorhinolaryngology-Head and Neck Surgery, Seoul St. Mary’s Hospital
#505 Banpo-dong, Seocho-gu, Seoul 06591, Korea
Tel: +82-2-2258-6213    Fax: +82-2-595-1354    E-mail: khpent@catholic.ac.kr                

Copyright © 2019 by The Korean Audiological Society and Korean Otological Society. All rights reserved.

Developed in M2community

Close layer
prev next