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J Audiol Otol > Epub ahead of print
DOI: https://doi.org/10.7874/jao.2019.00318    [Epub ahead of print] Published online November 4, 2019.
Comparison of the Effects of Intratympanic Steroid Injection at Different Intervals in Sudden Sensorineural Hearing Loss
Han Kyung Sung  , Ju Chang Kang  , Kyu Ha Shin  , Yun Suk An 
Department of Otorhinolaryngology-Head and Neck Surgery, Bundang Jesaeng Hospital, Daejin Medical Center, Seongnam, Korea
Correspondence  Yun Suk An ,Tel: +82-31-779-0258, Fax: +82-31-779-0265, Email: stella23@dmc.or.kr
Submitted: July 31, 2019  Accepted after revision: October 4, 2019
Abstract
Background and Objectives
Systemic steroid therapy (SST) and intratympanic steroid injection (ISI) have been the treatment of choice for sudden sensorineural hearing loss (SSNHL). We studied the effect of ISI administered at different intervals on hearing outcomes in patients with SSNHL.
Subjects and Methods
We performed a retrospective study of 427 patients diagnosed with SSNHL at Bundang Jesaeng Hospital, of whom 51 patients with SSNHL who received SST and four ISIs were included in this study. Patients were treated with four ISIs either every day for 4 days (group 1) or at intervals (mean duration of interval: 2.21 days) (group 2). Hearing outcomes were evaluated using the pure-tone test before the injection and 14 days, 1 month, and 3 months after the final injection. Recovery rates were classified based on Siegel’s criteria.
Results
The amount of improvement was 27.67 dB (±20.45) in group 1 and 32.79 dB (±21.42) in group 2. However, there were no significant differences between the two groups (p= 0.714). The recovery rates based on Siegel’s criteria were 18/27 (66.7%) and 16/24 (66.7%) in groups 1 and 2, respectively, with no significant difference (p=1.000). Considering only complete recoveries in hearing recovery, the recovery rates were 15/27 (55.6%) and 14/24 (58.3%) in groups 1 and 2, respectively, with no significant difference (p=0.842).
Conclusions
There were no significant differences in hearing outcomes or recovery rates after ISI administration every day or at intervals of 2-3 days.
Keywords: Correction of hearing loss · Intratympanic injection · Sensorineural hearing loss


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