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J Audiol Otol > Epub ahead of print
[Epub ahead of print] Published online January 5, 2018.
Clinical Safety and Efficacy of Autologous Bone Marrow-Derived Mesenchymal Stem Cell Transplantation in Sensorineural Hearing Loss Patients
Ho Seok Lee1, Woo Jin Kim2, Ji Sun Gong1, Kyoung Ho Park1
1Department of Otorhinolaryngology-Head and Neck Surgery, The Catholic University of Korea College of Medicine, Seoul, Korea
2Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, Korea
Correspondence  Kyoung Ho Park ,Tel: +82-2-2258-6213, Fax: +82-2-595-1354, Email: khpent@catholic.ac.kr
Submitted: June 8, 2017  Accepted after revision: August 3, 2017
Abstract
Stem cell transplantation represents a promising therapy for several degenerating and necrotic diseases. In several animal studies, we could find hearing restoration after inoculation of the mesenchymal stem cells' as well as mesenchymal stem cells' differentiation of hair cells and spiral ganglion. But until now, no clinical study has been reported directly for the human being. In this pilot studies, we applied mesenchymal stem cells to human beings trans-venously. Although we verified the safety of the autologous bone marrow stem cell transplantation in sensorineural hearing loss patients but we could not achieve significant improvement in hearing.
Keywords: Sensorineural hearing loss · Bone marrow derived mesenchymal stem cell · Electrical stimulation


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Department of Otorhinolaryngology-Head and Neck Surgery, Seoul St. Mary’s Hospital
#505 Banpo-dong, Seocho-gu, Seoul 06591, Korea
Tel: +82-2-2258-6213    Fax: +82-2-595-1354    E-mail: khpent@catholic.ac.kr                

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